Position Title

Research Scientist – Neuroscience




Vaccinex is a clinical-stage biotechnology company engaged in the discovery and development of targeted biotherapeutics to treat serious diseases with unmet medical needs, including neurodegenerative diseases, cancer and autoimmune disorders. We believe we are the leader in the field of semaphorin 4D (SEMA4D) biology, and that we are the only company evaluating SEMA4D blockade as a potential treatment for neurodegenerative diseases, cancer or autoimmune disorders, with several ongoing clinical trials in oncology and Huntington’s Disease.



The Vaccinex research team is seeking an experienced research scientist with the freedom and knowledge to conceive and execute hands-on studies investigating the role of glial cells in underlying biology of neurodegenerative diseases. The successful candidate will establish in vitro glial and neuronal models to identify and validate innovative therapeutic targets. The candidate will also evaluate the mechanism of action of therapeutic antibodies and biotherapeutics in various rodent mouse models of neuroinflammation. Knowledge of human and rodent anatomy and histology is required to evaluate target engagement in the context inflammatory and neurodegenerative processes. Excellent communication and teamwork will be critical. Candidates who aspire to contribute to innovative and scientifically driven translational research in a collaborative team environment, who are independent and motivated to build and develop experimental models, identify and investigate novel targets, face challenges with a positive attitude, and dedicated to high quality research to support clinical progress, are encouraged to apply. Candidates will enjoy a collaborative environment that fosters scientific innovation, self-motivated successes, and values employee wellness and quality of work/life balance.


Specific Skills/Experience Required for Posted Position

  1. Knowledge and technical expertise in neuroscience is required. Experience with related in vivo and in vitro assays, including 2D and 3D culture of primary neuronal and glial cells, functional assays, and immunohistochemistry is preferred.
  2. Knowledgeable of antibody discovery processes and relevant experience is a plus.



  1. Establish in vitro 2D and 3D culture of neuronal and glial cells using primary and iPSC-derived models of disease.
  2. Perform immunohistochemical, biochemical and behavioral analyses of mouse models of neurodegenerative diseases. Conduct in vivo experimental work (clinical scoring, motor testing and tissue collection) using rodent models of neurodegeneration.
  3. Implementation of cutting edge multiplex immunohistochemistry and microscopy.
  4. Analyze, interpret, and effectively communicate experimental results at lab meetings.
  5. Communicate and present work via email, personal communication, and oral presentation.
  6. Publish/present findings in peer-reviewed journals/scientific conferences.
  7. Able to direct the work flow of others.
  8. Benchwork may require use of hazardous chemicals and biologics, use of highly technical and automated equipment. Equipment and instrumentation may include incubators, fume hoods, ELISA plate washers, flow cytometer, microscope, HPLC, etc. Processes may include, but not limited to, electrophoresis, ELISA, cell culture and biological assays, chromatography, histochemistry, molecular biology, etc. May require work in a biosafety cabinet (including BSL2, human tissues and/or blood, vaccinia virus, etc), use of radioactive materials, recombinant DNA technology, and/or work with laboratory animals.
  9. The scope of work may require several consecutive hours of standing, moving, or sitting. Light lifting may be required. Personal protective equipment is required, including safety glasses, gloves, labcoats, etc.
  10. Some travel may be required.
  11. Requires proficiency with computers and use of Microsoft Word, Powerpoint, and Excel; may also require use of other computerized data acquisition and analysis software such as FloJo, Graphpad, etc.



  1. PhD in neuroscience or related field, or B.S. or MS in a related discipline with a minimum of three (3) years of significant and outstanding experience.
  2. Experience in the biopharmaceutical industry is a plus.
  3. Primarily self-directed and to be highly motivated to drive the above activities. In addition, a very high level of overall productivity is expected. Demonstrated ability to follow direction and established scientific protocols.
  4. Capable of making detailed observations, analyzing data, and interpreting results.
  5. Expected to prepare technical reports, summaries, protocols, and quantitative analyses.
  6. Possess good verbal and written communication skills, and good organizational skills.
  7. Independent, able to multi-task and results-oriented with a hands-on attitude in a fast-paced and energetic small company environment with limited daily supervision.
  8. The routine physical requirements of the job may include, but may not necessarily be limited to, lifting of up to 40 lbs., repetitive bending and reaching, and prolonged periods of sitting and standing.


Please Note: Due to the high volume of responses, only inquiries from qualified candidates can be addressed.

No telephone inquiries or recruiters, please.

Vaccinex, Inc. is an equal opportunity employer.

Please send resume via e-mail to resume@vaccinex.com.