Vaccinex Announces Publication of Vaccinex-Authored Review of SEMA4D in Oncoimmunology

ROCHESTER, N.Y., Oct. 28, 2015 /GlobalNews / — Vaccinex Inc., a clinical-stage biotechnology company engaged in the discovery and development of therapeutic monoclonal antibodies to treat cancer and neurodegenerative diseases, today announced publication of a manuscript entitled “Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D” as an invited “Author’s View” in the journal Oncoimmunology (Volume 4, Issue 12, 2015).  The review establishes the basis for targeting SEMA4D intervention in oncology via its role in immune cell trafficking and release of immunosuppression.  Further, it provides rationale for combinatorial therapies in oncology with other immune-modulating agents including checkpoint inhibitors that will be the focus of phase 2 clinical trials involving VX15/2503, an anti-SEMA4D antibody discovered and under development by Vaccinex.  The paper can be accessed via the following link:


About Vaccinex, Inc.

Vaccinex, Inc. is a privately held clinical-stage immunotherapy company engaged in the discovery and development of human therapeutic monoclonal antibodies to treat cancer and neurodegenerative diseases. The Company has completed phase 1 clinical trials in solid tumors and multiple sclerosis and is currently engaged in a phase 2 clinical trial in Huntington’s disease. Vaccinex utilizes its proprietary ActivMAb® Antibody Discovery Technology for rapid, mammalian cell-based antibody selection to build its antibody pipeline and in service to its biopharmaceutical partners. ActivMAb® combines the advantages of rapid and sensitive selection by virus panning and cell sorting in one technology, with intrinsic selection of antibodies that are efficiently expressed in mammalian cells and have desirable solubility and stability properties. Vaccinex is based in Rochester, New York. For more information and to contact Vaccinex, visit


CONTACT: Vaccinex


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