VX15

Saturation Monitoring of VX15/2503, a Novel Semaphorin 4D-Specific Antibody, in Clinical Trials
Cytometry Part B (Clinical Cytometry) 90B:199–208 (2016)
Terrence L. Fisher, Jennifer Seils, Christine Reilly, Virginia Litwin, Lisa Green, Janelle Salkowitz-Bokal, Robin Walsh, Sarah Harville, John E. Leonard, Ernest Smith, and Maurice Zauderer <PDF>
Immunomodulation of the tumor microenvironment by neutralization of Semaphorin 4D
Oncoimmunology. Volume 4, Issue 12, 2015
Elizabeth E Evans, Mark Paris, Ernest S Smith & Maurice Zauderer <PDF>
Safety, Pharmacokinetics and Pharmacodynamics of a Humanized anti-Semaphorin 4D Antibody, in a First-In-Human Study of Patients with Advanced Solid Tumors
Clin Cancer Res; Published OnlineFirst October 7, 2015
Amita Patnaik, Glen J Weiss, John E Leonard, Drew Rasco, Jasgit C. Sachdev, Terrence L Fisher, Laurie A Winter, Christine Reilly, Robert B Parker, Danielle Mutz, Lisa Blaydorn, Anthony W Tolcher, Maurice Zauderer, and Ramesh K Ramanathan <PDF>
Generation and preclinical characterization of an antibody specific for SEMA4D
MAbs. 2015 Oct 2:0
Fisher TL, Reilly CA, Winter LA, Pandina T, Jonason A, Scrivens M, Balch L, Bussler H, Torno S, Seils J, Mueller L, Huang H, Klimatcheva E, Howell A, Kirk R, Evans E, Paris M, Leonard JE, Smith ES, Zauderer M. <PDF>
Antibody blockade of semaphorin 4D promotes immune infiltration into tumor and enhances response to other immunomodulatory therapies.
Cancer Immunol Res. 2015 Jan 22. – January 2015
Elizabeth E. Evans, Holm Bussler, Sebold Torno, Janaki Veeraraghavan, Alan S. Jonason, Jr., Christine Reilly, Jennifer Seils, Maria Scrivens, Michael A. Doherty, Crystal Mallow, Alan Howell, Renee Kirk, Susan Giralico, Katya Klimatcheva, John E. Leonard, Terrence L. Fisher, William Bowers , Mark Paris, Ernest S. Smith, Maurice Zauderer <PDF>
SEMA4D compromises blood–brain barrier, activates microglia, and inhibits remyelination in neurodegenerative disease
Neurobiol Dis. 2014 Oct 18;73C:254-268 – October 2014
Ernest S. Smith, Alan Jonason, Christine Reilly, Janaki Veeraraghavan, Terrence Fisher, Chad Cornelius, Michael Doherty, Ekaterina Klimatcheva, Nicola Marchi, Damir Janigro, Azeb Tadesse Argaw, Trinh Pham, Jennifer Seils, Holm Bussler, Sebold Torno, Renee Kirk, Alan Howell, Elizabeth E. Evans, Mark Paris, William J. Bowers, Gareth John, and Maurice Zauderer <PDF>
Anti-semaphorin 4D immunotherapy ameliorates neuropathology and some cognitive impairment in the YAC128 mouse model of Huntington disease.
Neurobiol Dis. 2015 Feb 3 – February 2015
Southwell AL, Franciosi S, Villanueva EB, Xie Y, Winter LA, Veeraraghavan J, Jonason A, Felczak B, Zhang W, Kovalik V, Waltl S, Hall G, Pouladi MA, Smith ES, Bowers WJ, Zauderer M, Hayden MR. <PDF>
Nonclinical Safety Evaluation of VX15/2503; a Humanized IgG4 Anti-SEMA4D Antibody
Mol Cancer Ther. 2015 Feb 5 – February 2015
John E. Leonard, Terrence L. Fisher, Laurie A. Winter, Chad A. Cornelius, Christine Reilly, Ernest S. Smith and Maurice Zauderer <PDF>

VX5

CXCL13 antibody for the treatment of autoimmune disorders
BMC Immunology 2015 Feb 12;16:6 – February 2015
Ekaterina Klimatcheva, Tracy Pandina , Christine Reilly, Sebold Torno, Holm Bussler, Maria Scrivens, Alan Jonason, Michael Doherty, Mark Paris, Ernest S Smith and Maurice Zauderer <PDF>
Anti-CXCL13 antibody can inhibit the formation of gastric lymphoid follicles induced by Helicobacter infection.
Mucosal Immunol. 2014 Sep;7(5):1244-54 – September 2014
Yamamoto K, Nishiumi S, Yang L, Klimatcheva E, Pandina T, Takahashi S, Matsui H, Nakamura M, Zauderer M, Yoshida M, Azuma T
CXCL13 is elevated in Sjogren’s syndrome in mice and humans and is implicated in disease pathogenesis
Journal of Leukocyte Biology, 94:1079-1089, 2013 – November 2013
Jill M. Kramer, Ekaterina Klimatcheva, and Thomas L. Rothstein <PDF>

Platform

Perfecting in vitro mammalian display for antibody selection
Nature Biotechnology – Biopharma Dealmakers, June 2015 (B14) <PDF>
Antibody library display on a mammalian virus vector: combining the advantages of both phage and yeast display into one technology
Curr Drug Discov Technol. 2014 Mar;11(1):48-55 – March 2014
Smith ES, Zauderer M. <PDF>
Antibody Selection from Immunoglobulin Libraries Expressed in Mammalian Cells.
In Therapeutic Antibodies: From Bench to Clinic. Edited by Zhiqiang An. 2009 p283-307. – January 2009
Smith ES, Zauderer M.
In vitro generation of tumor specific T cells that recognize a shared antigen of AML: molecular characterization of TCR genes.
Leuk Res. 2007 Feb;31(2):195-202 – February 2007
Coppage M, Belanger T, Zauderer M, Sahasrabudhe D.
Construction of cDNA Libraries in Vaccinia Virus
Methods in Molecular Biology 269: 65-75 – January 2004
Smith, E.S., S. Shi, and M. Zauderer
Lethality-Based Selection of Recombinant Genes in Mammalian Cells: Application to Identifying Tumor Antigens
Nature Medicine 7: 967-972. 2001 – August 2001
Smith, E S.., A. Mandokhot, E. Evans, L. Mueller, M.A. Borrello, D. Sahasrabudhe, and M. Zauderer.
Construction and characterization of vaccinia direct ligation vectors.
Virology. 1997 Nov 24;238(2):444-51. – November 1997
Merchlinsky M, Eckert D, Smith E, Zauderer M. <PDF>

VX35

C35: A new Prognostic Tool and Potential Target in Prostate Cancer
ASCO 2013 Genitourinary Cancers Symposium – January 2013
Deepak Kilari, Jorge Yao, Emil Scosyrev, Elizabeth Evans, and Deepak Sahasrabudhe
A gene on the HER2 amplicon, C35, is an oncogene in breast cancer whose actions are prevented by inhibition of Syk.
British Journal of Cancer (2010), 1 –10 – July 2010
E Katz, S Dubois-Marshall, AH Sims, D Faratian, J Li, ES Smith, JA Quinn, M Edward, RR Meehan, EE Evans, SP Langdon and DJ Harrison <PDF>
C35 (C17orf37) Is A Novel Tumor Biomarker Abundantly Expressed in Breast Cancer
Mol Cancer Ther. 5(11):2919–30 – November 2006
Evans, E.E., Henn, A.D., Jonason, A., Paris, M.J., Schiffhauer, L.M., Borrello, MA, Smith, ES, Sahasrabudhe DM, Zauderer M <PDF>

NKT

CD1d-antibody fusion proteins target iNKT cells to the tumor and trigger long-term therapeutic responses.
Cancer Immunol Immunother. 2013 Apr;62(4):747-60 – April 2013
Corgnac S, Perret R, Derré L, Zhang L, Stirnemann K, Zauderer M, Speiser DE, Mach JP, Romero P, Donda A. <PDF>
Sustained activation and tumor targeting of NKT cells using a CD1d-anti-HER2-scFv fusion protein induce antitumor effects in mice.
J Clin Invest. 2008 Mar;118(3):994-1005 – March 2008
Stirnemann K, Romero JF, Baldi L, Robert B, Cesson V, Besra GS, Zauderer M, Wurm F, Corradin G, Mach JP, Macdonald HR, Donda A. <PDF>