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Maximize your chances for success against difficult protein targets.

What is Antigen Virus?

We have leveraged our knowledge of poxvirus biology to create a technology where multi-pass membrane proteins are expressed in the viral lipid membrane for antibody discovery.  

The antigen virus membrane is derived from the Golgi and not the cell membrane. Fewer non-target proteins are incoporated as compared to standard VLPs.

Cartoon of mammalian poxvirus in blue with GPCR proteins embedded in the outer membrane.

Mammalian Poxvirus

Vaccinex offers two antigenically distinct poxviruses to facilitate antibody selection.  Both the mammalian and the avian poxviruses are compatible with in vivo and in vitro antibody discovery methods.

Cartoon of an avian poxvirus in pink with a GPCR embedded in the outer membrane.

Avian Poxvirus

How can I use antigen virus?

Antigen virus is Biosafety Level 1 and can be used safely on the benchtop.  Applications include immunization of animals, phage panning and ELISA.

Icon of a mouse facing left in silouhette with in teal with a white antibody stencil in the center.

Antigen virions can be used to immunize animals to discover antibodies against complex membrane proteins. 

Image of  a phagemid in silhouette in teal with a stencil of a white antibody in the center.

Antigen virions can be coupled to magnetic beads or coated on ELISA plates for phage display methods.

Cartoon of an antibody molecule in teal.

Our poxvirus technology can also express full-length mammalian antibody libraries for in vitro discovery.

We have both catalog and custom  antigen virus options available!

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