ActivMAb® Discovery Solutions
Whether you need Antibody Discovery, Complex Membrane Antigens, Target Identification, or Protein Optimization, our ActivMAb® Discovery services offer unique solutions to assist in your Drug Discovery and Development projects.
Let us help you move faster from bench to clinic.
Vaccinex has developed a proprietary mammalian cell based antibody discovery platform with unique multi-pass membrane target capabilities. The Activmab technology now has four main applications:
Complex Membrane Antigen Virus
- direct incorporation of multipass membrane proteins into the viral membrane.
- proven expression of many GPCRS and Ion Channels
- no detergents or refolding needed for properly folded protein
- suitable for antibody discovery including in vitro display methods and immunization
Antibody Discovery
- library of human antibodies in full length IgG format
- IgG expressed on the surface of both a mammalian virus and cell
- rapid selection of >1010 antibody combinations
- selected antibodies are ideally suited for development
Protein Optimization
- optimization of protein expression by mutagenesis
- selection for desired variants in a fully mammalian cell system
Antigen Discovery
- large antigen libraries in a mammalian virus
- identify the unknown targets of orphaned binding molecules